Clinical & Healthcare Research
PUBLICATIONS from 2018

 Link for all publications:
 mantke r - Search Results - PubMed


Gender differences in gastric cancer care and its adherence to guidelines in Germany (MaGen): protocol for an observational retrospective cohort study with administrative routine and cancer registry data from 2017 to 2021.

Weber U, Kreß L, Hunger R, Schildberg C, Mantke R.

BMJ Open. 2026 Feb 2;16(2):e103467. doi: 10.1136/bmjopen-2025-103467.

Validation of the new "Brandenburg Acute Bile Duct (BABD) injury classification" system in 106 patients with accidental bile duct injuries during cholecystectomy.

Mantke R, Hafkesbrink J, Ch P, Hunger R.

Patient Saf Surg. 2026 Jan 12;20(1):6. doi: 10.1186/s13037-025-00451-1. 

Using antibiotic prophylaxis to reduce surgical site infection after shouldice repair.

Paasch C, Netto FAS, Svendrovski A, Mantke R, Mainprize M.

Hernia. 2026 Jan 6;30(1):55. doi: 10.1007/s10029-025-03570-x. 

Trends in operative treatment of the rectus diastasis A 13 year analysis of German nationwide hospital discharge data.

Paasch C, Lorenz R, Lünse S, Mainprize M, Wendland O, Hunger R, Mantke R.

Langenbecks Arch Surg. 2025 Dec 22;411(1):38. doi: 10.1007/s00423-025-03950-y. 

Sex and Age Differences in Clinicopathological Characteristics of Gastric Cancer.

Schildberg C, Weber U, Dietrich N, Seeland U, Mantke R.

J Clin Med. 2025 Nov 7;14(22):7894. doi: 10.3390/jcm14227894. 

Clinical health service research on single-incision laparoscopic colon and rectal surgery: results of 1,170 patients in a 7-year registry analysis.

Sahm M, Fricke M, Stirn V, Hunger R, Croner R, Lippert H, Mantke R.

Surgery. 2025 Dec;188:109672. doi: 10.1016/j.surg.2025.109672. Epub 2025 Sep 13. 

The Impact of Perioperative Antibiotic Prophylaxis on Surgical Site Infections in Laparoscopic Gastric Bypass Surgery: A Single Center Analysis Among 494 Patients.

De Santo G, Stumpf O, Hunger R, Look P, Abdelmalek M, Hünerbein M, Mantke R, Paasch C.

Obes Surg. 2025 Oct;35(10):4299-4308. doi: 10.1007/s11695-025-08218-4. Epub 2025 Sep 9. 

 "Two-stage resection of synchronous liver metastases in colorectal cancer leads to a survival benefit: a retrospective comparative cohort study".

Lünse S, von Ruesten A, Schneider C, Gretschel S, Loew A, Mantke R.

Langenbecks Arch Surg. 2025 Aug 28;410(1):253. doi: 10.1007/s00423-025-03840-3. 

Real-world data of single-incision laparoscopic appendectomy: a German-wide prospective cohort study among 276 individuals.

Matzner JM, Paasch C, Stirn V, Hunger R, Lünse S, Lippert H, Croner R, Mantke R.

Ann Med Surg (Lond). 2025 Jul 10;87(8):4758-4764. doi: 10.1097/MS9.0000000000003478. eCollection 2025 Aug. 

Anticipated effects of centralising complex gastrointestinal surgery in a rural area in Germany - perspective of health professionals: a qualitative study.

Kugler CM, Gretschel S, Scharfe J, Pfisterer-Heise S, Mantke R, Pieper D.

BMC Health Serv Res. 2025 Jun 28;25(1):824. doi: 10.1186/s12913-025-12982-5. 

 
Laparoscopic appendectomy as the gold standard: What role remains for open surgery, conversion, and disease severity? : An analysis of 32,000 cases with appendicitis in Germany.

Schildberg C, Weber U, König V, Linnartz M, Heisler S, Hafkesbrink J, Fricke M, Mantke R.

World J Emerg Surg. 2025 Jun 18;20(1):53. doi: 10.1186/s13017-025-00626-2. 

Mortality after total pancreatectomy in an observational nationwide cohort study.

Mantke R, Weber U, Schildberg C, Hunger R, Büchler M.

Br J Surg. 2025 May 31;112(6):znaf091. doi: 10.1093/bjs/znaf091.

Gastric Cancer in the Countryside or in the City: Does the Prognosis Change? An Analysis from the German States of Brandenburg and Berlin.

Loew A, von Ruesten A, Schneider C, Mantke R, Weylandt KH, Gretschel S.

Curr Oncol. 2025 Apr 14;32(4):228. doi: 10.3390/curroncol32040228.

Increasing the rates of pre-operative stoma site marking in patients with intestinal ostomy (INSTOSI): a best practice implementation project.

Shehu E, Pieper D, Albrecht HC, Gretschel S, Krüger CM, Leggio F, Mantke R, Rückbeil O, Paasch C, Trawa M, Klugarová J, Peričić TP, Bała MM, Prill R, Kugler CM.

JBI Evid Implement. 2025 Apr 17. doi: 10.1097/XEB.0000000000000503. Online ahead of print. 

 
Analgesic efficacy of a laparoscopic-guided transversus abdominis plane block versus no transversus abdominis plane block in bariatric gastric bypass surgery a retrospective analysis among 332 individuals.

De Santo G, Stumpf O, Look P, Abdelmalek M, Lefering R, Mantke R, Paasch C.

BMC Surg. 2025 Apr 4;25(1):136. doi: 10.1186/s12893-025-02880-2. 

Not Only Caseload but Also Patient Selection Is Predictive of Mortality After Pancreatic Resection.

Mantke R, Seliger B, Ogino S, Büchler MW, Hunger R.

Ann Surg Open. 2024 Dec 30;6(1):e536. doi: 10.1097/AS9.0000000000000536. eCollection 2025 Mar. 

Surgeons' opinions and concerns regarding prophylactic mesh placement when conducting a permanent ileo- and colostomy A survey among 172 surgeons in Germany, Switzerland, and Austria.

Paasch C, Kalmykov EL, Lorenz R, Neveling N, Mantke R.

Front Surg. 2024 Nov 29;11:1479870. doi: 10.3389/fsurg.2024.1479870. eCollection 2024.

Quality of life following Shouldice Repair: a prospective cohort study among inguinal hernia patients.

Mainprize M, Spencer Netto FAC, Svendrovski A, Mantke R, Paasch C.

Hernia. 2024 Nov 23;29(1):28. doi: 10.1007/s10029-024-03217-3. 

Is there a link between Spigelian and inguinal hernias? A case series.

Lorenz R, Vollmer U, Conze J, Loch F, Paul-Promchan K, Mantke R, Paasch C, Wiessner R.

Hernia. 2024 Oct;28(5):1737-1746. doi: 10.1007/s10029-024-03061-5. Epub 2024 Jun 27.

Patients with stage IV colorectal carcinoma selected for palliative primary tumor resection and systemic therapy survive longer compared with systemic therapy alone: a retrospective comparative cohort study.

Mantke R, Schneider C, von Ruesten A, Hauptmann M.

Int J Surg. 2024 Oct 1;110(10):6493-6500. doi: 10.1097/JS9.0000000000001838. 

[Treatment reality of esophageal cancer in the Federal State of Brandenburg : Comparison between squamous cell carcinoma and adenocarcinoma].

Loew A, Schneider C, Pflüger M, Mantke R, Weylandt KH, Gretschel S.

Chirurgie (Heidelb). 2024 Oct;95(10):825-832. doi: 10.1007/s00104-024-02110-0. Epub 2024 Jun 11.

PMID: 38861172 Free PMC article. German. 

Outcome variation and the role of caseload in certified colorectal cancer centers - a retrospective cohort analysis of 90 000 cases.

Hunger R, Kowalski C, Paasch C, Kirbach J, Mantke R.

Int J Surg. 2024 Jun 1;110(6):3461-3469. doi: 10.1097/JS9.0000000000001285. 

Placing vacuum sponges in esophageal anastomotic leaks - how we do it.

Hentschel F, Mollenhauer G, Siemssen B, Paasch C, Mantke R, Lüth S.

Langenbecks Arch Surg. 2024 Mar 5;409(1):86. doi: 10.1007/s00423-024-03272-5. 

Incidence of incisional hernias and cosmetic outcome after laparoscopic single-incision cholecystectomy: a long-term follow-up cohort study of 125 patients.

Krollmann N, Hunger R, Paasch C, Mantke R.

Ann Med Surg (Lond). 2023 Nov 16;86(1):50-55. doi: 10.1097/MS9.0000000000001442. eCollection 2024

[Effects of new minimum volume standards in visceral surgery on healthcare in Brandenburg, Germany, from the perspective of healthcare providers].

Kugler CM, Gretschel S, Scharfe J, Pfisterer-Heise S, Mantke R, Pieper D.

Chirurgie (Heidelb). 2023 Dec;94(12):1015-1021. doi: 10.1007/s00104-023-01971-1. Epub 2023 Oct 26. 

How often is prophylactic parastomal mesh placement performed after rectal resection without sphincter preservation? An analysis of German nationwide hospital discharge data among 41,697 patients.

Paasch C, Kobelt E, Lünse S, Heisler S, Lorenz R, Hunger R, Mantke R.

Hernia. 2024 Feb;28(1):9-15. doi: 10.1007/s10029-023-02887-9. Epub 2023 Oct 16. 

The effect of biofeedback pelvic floor training with ACTICORE1 on urinary incontinence: a multicenter randomized clinical pilot trial.

Paasch C, Soeder S, Lorenz E, Heisler S, Götze M, Borgmann H, Olthoff J, Hünerbein M, Hunger R, Mantke R.

Ann Med Surg (Lond). 2023 Aug 18;85(10):4860-4865. doi: 10.1097/MS9.0000000000001181. eCollection

Drain versus no drain in elective open incisional hernia operations: a registry-based analysis with 39,523 patients.

Sahm M, Pross M, Hukauf M, Adolf D, Köckerling F, Mantke R.

Hernia. 2024 Aug;28(4):1077-1091. doi: 10.1007/s10029-023-02862-4. Epub 2023 Aug 18. 

 The effect of an abdominal binder on postoperative outcome after open incisional hernia repair in sublay technique: a multicenter, randomized pilot trial (ABIHR-II).

Ortiz PR, Lorenz E, Meyer F, Croner R, Lünse S, Hunger R, Mantke R, Benz-Weisser A, Zarras K, Huenerbein M, Paasch C.

Hernia. 2023 Oct;27(5):1263-1271. doi: 10.1007/s10029-023-02838-4. Epub 2023 Jul 19. 

 A contemporary assessment of total neoadjuvant therapy (TNT) protocols for locally advanced rectal cancer: adoption and expert perspectives at German Cancer Society (DKG)-certified colorectal cancer centers.

Langheinrich M, Paasch C, Mantke R, Weber K, Benz S, Kersting S.

J Cancer Res Clin Oncol. 2023 Oct;149(13):12591-12596. doi: 10.1007/s00432-023-05139-6. Epub 2023 

Optimal timing for antimicrobial prophylaxis to reduce surgical site infections: a retrospective analysis of 531 patients.

Paasch C, Schildberg C, Lünse S, Heisler S, Meyer J, Kirbach J, Kobelt E, Hunger R, Haller IE, Helmke C, Mantke R.

Sci Rep. 2023 Jun 9;13(1):9405. doi: 10.1038/s41598-023-36588-1. 

Diagnostic, Therapy and Complications in Acute Appendicitis of 19,749 Cases Based on Routine Data: A Retrospective Multicenter Observational Study.

Schildberg CW, Reissig K, Hunger R, Paasch C, Stillger R, Mantke R.

J Clin Med. 2022 Aug 2;11(15):4495. doi: 10.3390/jcm11154495. 

[A rare cause of left-sided epigastric pain].

von Frankenberg J, Schildberg C, Schreyer AG, Hippe S, Paasch C, Mantke R.

Chirurgie (Heidelb). 2022 Sep;93(9):902-904. doi: 10.1007/s00104-022-01649-0. Epub 2022 May 31. 

Impact of the COVID-19 pandemic on delays in surgical procedures in Germany: a multi-center analysis of an administrative registry of 176,783 patients.

Hunger R, König V, Stillger R, Mantke R.

Patient Saf Surg. 2022 Jun 28;16(1):22. doi: 10.1186/s13037-022-00331-y.

Mortality factors in pancreatic surgery: A systematic review. How important is the hospital volume?

Hunger R, Seliger B, Ogino S, Mantke R.

Int J Surg. 2022 May;101:106640. doi: 10.1016/j.ijsu.2022.106640. Epub 2022 May 4. 

 
The effect of biofeedback pelvic floor training with ACTICORE1 on fecal incontinence A prospective multicentric cohort pilot study.

Paasch C, Bruckert L, Soeder S, Von Frankenberg J, Mantke R, Lorenz E, Andric M, Wiede A, Strack A, Hünerbein M, Croner S.

Int J Surg. 2022 May;101:106617. doi: 10.1016/j.ijsu.2022.106617. Epub 2022 Apr 15. 

[Epidemiology and surgical treatment of pancreatic cancer in the State of Brandenburg : Analysis of 5418 cases].

Mantke R, Schneider C, Weylandt K, Gretschel S, Marusch F, Kube R, Loew A, Jaehn P, Holmberg C, Hunger R.

Chirurgie (Heidelb). 2022 Aug;93(8):788-801. doi: 10.1007/s00104-021-01561-z. Epub 2022 Jan 7. 

 [Reality of care of colorectal cancer in the State of Brandenburg : With special consideration of the number of hospital cases and certification as a colorectal cancer center].

Sahm M, Schneider C, Gretschel S, Kube R, Becker A, Günther M, Loew A, Jahnke K, Mantke R.

Chirurg. 2022 Mar;93(3):274-285. doi: 10.1007/s00104-021-01468-9. Epub 2021 Aug 10. 

Outcome Quality Beyond the Mean - An Analysis of 43,231 Pancreatic Surgical Procedures Related to Hospital Volume.

Hunger R, Mantke R.

Ann Surg. 2022 Jul 1;276(1):159-166. doi: 10.1097/SLA.0000000000004315. Epub 2020 Nov 23. 

 [Reliability of DRG Routine Data to Analyse Treatment Outcome and Complications of Thyroid Surgery. A Critical Analysis of Data of Patient Records Compared to Administrative Data].

Sahm M, Riegel C, Mantke A, Reissig K, Hunger R, Mantke R.

Zentralbl Chir. 2021 Feb;146(1):76-82. doi: 10.1055/a-1101-9699. Epub 2020 Feb 10. 

[Morbidity and Mortality of Single Incision Cholecystectomy: Results of a 3-Year Register Analysis].

Sahm M, Reinsch AK, Otto R, Mönch C, Gerdes M, Winde G, Lancee S, Meyer L, Mantke A, Lippert H, Croner R, Mantke R.

Zentralbl Chir. 2020 Aug;145(4):390-398. doi: 10.1055/a-1071-8082. Epub 2020 Feb 3. 

Hospital volume and mortality in liver resections for colorectal metastasis using population-based administrative data.

Hunger R, Mantke A, Herrmann C, Grimm AL, Ludwig J, Mantke R.

J Hepatobiliary Pancreat Sci. 2019 Dec;26(12):548-556. doi: 10.1002/jhbp.680. Epub 2019 Oct 24. 

Laparoscopic therapy of the coeliac artery compression syndrome: a critical analysis of the current standard procedure.

Sahm M, Otto R, Pross M, Scholbach T, Mantke R.

Ann R Coll Surg Engl. 2020 Feb;102(2):104-109. doi: 10.1308/rcsann.2019.0121. Epub 2019 Sep 11. 

[Investigations on fatalities due to liver resection in Germany : Evaluation of the German Society for General and Visceral Surgery certification regulations for liver centers based on routine diagnosis-related groups data].

Hunger R, Mantke A, Herrmann C, Mantke R.

Chirurg. 2020 Aug;91(8):662-669. doi: 10.1007/s00104-019-1012-3. 

 Minimally invasive video-assisted thyroidectomy: a critical analysis of long-term cosmetic results using a validated tool.

Sahm M, Otto R, Pross M, Mantke R.

Ann R Coll Surg Engl. 2019 Mar;101(3):180-185. doi: 10.1308/rcsann.2018.0178. Epub 2018 Oct 16. 

 [Triclosan-coated sutures in colorectal surgery : Assessment and meta-analysis of the recommendations of the WHO guideline].

Hunger R, Mantke A, Herrmann C, Mantke R.

Chirurg. 2019 Jan;90(1):37-46. doi: 10.1007/s00104-018-0732-0. 

[Factors Affecting Long-Term Cosmetic Results after Minimally Invasive Video-Assisted Thyroidectomy and Conventional Thyroid Surgery].

Sahm M, Otto R, Pross M, Mantke R.

Zentralbl Chir. 2018 Aug;143(4):385-391. doi: 10.1055/a-0600-9910. Epub 2018 Jun 25. 

AI & Training & Translational Research
PUBLICATIONS from 2018

ChatGPT in general surgery: a cross-sectional study assessing its response to patient questions.

Lünse S, Wisotzky EL, Höhn J, Paasch C, Meyer F, Hunger R, Mantke R.

Ann Med Surg (Lond). 2025 Sep 24;87(11):7088-7094. doi: 10.1097/MS9.0000000000003939. eCollection 2025 Nov. 

Vascular diameter determines sensitivity to soluble guanylate cyclase activation in human mesenteric and renal arteries.

Lubomirov LT, Jasinski-Bergner S, Li K, Metzler D, Korotkova T, Hescheler J, Pfitzer G, Todorov VT, Mantke R, Enzmann T, Borgmann H, Grisk O.

Vascul Pharmacol. 2025 Sep;160:107515. doi: 10.1016/j.vph.2025.107515. Epub 2025 Jun 11.

[The doctoral regulations of the medical faculties in Germany : What has changed in the last 9 years?].

van Bergen T, Paasch C, Hunger R, Mantke R.

Chirurgie (Heidelb). 2025 Oct 2. doi: 10.1007/s00104-025-02387-9. Online ahead of print.

Inter-hospital transferability of AI: A case study on phase recognition in cholecystectomy.

Renz-Kiefel L, Lünse S, Mantke R, Eisert P, Hilsmann A, Wisotzky EL.

Comput Biol Med. 2025 Jun;192(Pt B):110235. doi: 10.1016/j.compbiomed.2025.110235. Epub 2025 May

The learning curve for the Shouldice Repair: a pilot analysis of post-training specialized surgeons at the Shouldice Hospital.

Paasch C, Hunger R, Szasz P, Yilbas A, Netto FACS, Mantke R, Mainprize M.

Hernia. 2025 Jan 23;29(1):70. doi: 10.1007/s10029-024-03252-0. 

Structured hernia surgery training program for general practitioners in Rwanda - feasibility and evaluation.

Lorenz R, Hubert L, Paasch C, Conze J, Oppong C, Akoh JA, Sedgwick DM, Nsabimana V, Mantke R.

Hernia. 2025 Jan 23;29(1):73. doi: 10.1007/s10029-025-03260-8. 

Colon Tumor Discrimination Combining Independent Endoscopic Probe-Based Raman Spectroscopy and Optical Coherence Tomography Modalities with Bayes Rule.

Vasquez DL, Kreft C, Latka I, Popp J, Mantke R, Schie IW.

Int J Mol Sci. 2024 Dec 11;25(24):13306. doi: 10.3390/ijms252413306.

Long-term evaluation of the Hernia Compact course of the German Hernia School.

Lorenz R, Paasch C, Stechemesser B, Reinpold W, Niebuhr H, Fortelny RH, Mayer F, Köckerling F, Mantke R.

Hernia. 2024 Apr;28(2):621-628. doi: 10.1007/s10029-024-02966-5. Epub 2024 Feb 23. 

Automated determination of 8-OHdG in cells and tissue via immunofluorescence using a specially created antibody.

Jung T, Findik N, Hartmann B, Hanack K, Grossmann K, Roggenbuck D, Wegmann M, Mantke R, Deckert M, Grune T.

Biotechnol Rep (Amst). 2024 Mar 2;42:e00833. doi: 10.1016/j.btre.2024.e00833. eCollection 2024 Jun.

Does the angle of trocar insertion affect the fascial defect caused? A porcine model.

Paasch C, Meyer J, Hunger R, Krollmann N, Heisler S, Mantke R.

Hernia. 2024 Apr;28(2):585-592. doi: 10.1007/s10029-023-02952-3. Epub 2024 Feb 6.

Technological advancements in surgical laparoscopy considering artificial intelligence: a survey among surgeons in Germany.

Lünse S, Wisotzky EL, Beckmann S, Paasch C, Hunger R, Mantke R.

Langenbecks Arch Surg. 2023 Oct 16;408(1):405. doi: 10.1007/s00423-023-03134-6.

ROK and RSK2-kinase pathways differ between senescent human renal and mesenteric arteries.

Lubomirov LT, Mantke R, Enzmann T, Metzler D, Korotkova T, Hescheler J, Pfitzer G, Grisk O.

J Hypertens. 2023 Jul 1;41(7):1201-1214. doi: 10.1097/HJH.0000000000003450. Epub 2023 Apr 27.

Quantification of mitochondrial cfDNA reveals new perspectives for early diagnosis of colorectal cancer.

Linke C, Hunger R, Reinwald M, Deckert M, Mantke R.

BMC Cancer. 2023 Mar 30;23(1):291. doi: 10.1186/s12885-023-10748-y.

Bladed and bladeless conical trocars do not differ in terms of caused fascial defect size in a Porcine Model.

Paasch C, Mantke A, Hunger R, Mantke R.

Surg Endosc. 2022 Dec;36(12):9179-9185. doi: 10.1007/s00464-022-09401-9. Epub 2022 Jul 18.

[Depth and integration of science modules in medical studies at recognized public and private faculties in Germany: A cross-sectional study].

Bauer J, Schendzielorz J, Oess S, Mantke R.

Z Evid Fortbild Qual Gesundhwes. 2022 Nov;174:90-96. doi: 10.1016/j.zefq.2022.08.006. Epub 2022 Sep

Must Clinics Replace 2D by 3D Environments for an Efficient Training of Laparoscopic Novices? A Critical Analysis of the Learning Curve for Basic Skills.

Sahm M, Danzer C, Grimm AL, Herrmann C, Mantke R.

Front Surg. 2022 Jan 17;8:792107. doi: 10.3389/fsurg.2021.792107. eCollection 2021.